Promethazine: Indicators and signs of overdosage with promethazine HCl range between moderate despair in the central nervous technique and cardiovascular system to profound hypotension,
If You can't return the medication, Examine the label or package insert to determine In case the medication needs to be thrown out within the rubbish or flushed down the rest room. If You aren't confident, request your treatment group.
Very long-time period animal experiments have not been performed to assess the carcinogenic prospective of codeine or of promethazine, nor are there other animal or human facts about carcinogenicity, mutagenicity, or impairment of fertility Using these agents.
Promethazine is additive to the depressant results of codeine. It is difficult to establish what constitutes a normal harmful or lethal dose. Having said that, the lethal oral dose of codeine in an adult is reported to get from the array of 0.five to one.0 gram. Infants and kids are thought to get somewhat more delicate to opiates with a physique-fat foundation. Elderly people will also be comparatively intolerant to opiates.
This medication can dry up and thicken mucus within your lungs, making it tougher to breathe and obvious your lungs. To help protect against this influence, drink a good amount of fluids Except if normally directed by your health care provider.
Codeine has fantastic antitussive exercise, While below that of morphine at equal doses. It's Employed in desire to morphine, mainly because Unwanted side effects are rare at the same old antitussive dose of codeine.
However it helps A lot of people, this medication contains a risk for abuse and may sometimes induce addiction. This chance may be higher if you have a substance use ailment (such as overuse of or dependancy to medication/Liquor).
Normally, dose selection for an aged affected person really should be careful, ordinarily starting up for the small finish in the dosing range, reflecting the better frequency of decreased hepatic, renal or cardiac function, and of concomitant illness or other drug therapy.
Just before using this medication, notify your medical doctor or pharmacist If you're allergic to promethazine or to dextromethorphan; or to some other phenothiazines (which include prochlorperazine); or For those who have some other allergic reactions.
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Bronchial asthma As well as other Respiratory Circumstances: Narcotic analgesics or cough suppressants, including codeine, should not be used in asthmatic individuals (see CONTRAINDICATIONS). Nor ought to they be Utilized in acute febrile illness connected with productive cough or in Long-term respiratory disorder where interference with power to obvious the tracheobronchial tree of secretions would've a deleterious impact on the affected individual’s respiratory function.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients under 6 several years of age, because the combination may perhaps lead to lethal respiratory depression On this age populace. It is crucial that Promethazine Hydrochloride and Codeine Phosphate Syrup is calculated using an correct measuring unit (see PRECAUTIONS- Facts for Individuals).
Codeine and its salts are very well absorbed following equally oral and parenteral administration. Codeine Promethazine codeine syrup is about two/3 as powerful orally as parenterally. Codeine is metabolized primarily from the liver by enzymes of your endoplasmic reticulum, the place it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.
Consume an abundance of fluids while you are utilizing this medication Except normally directed by your health care provider. The fluid should help loosen the mucus within your lungs.